10. There's absolutely nothing useful about suffering.

He'd subscribed to this credo for years and years-had felt deeply indebted to Caroline for each remark-and now he wondered how much of it was true. Maybe none of it.

"I'm calling the travel agent tomorrow morning," he said.

"And I'm telling you," Caroline replied immediately, "call Dr. Pierce instead. You need to talk to somebody."

"I need somebody who tells the truth."

"You want the truth? You want me to tell you why I'm not going?" Caroline sat up and leaned forward at the funny angle that her backache dictated. "You really want to know?"

Gary's eyes fell shut. The crickets outside sounded like water running interminably in pipes. From the distance came a rhythmic canine barking like the downthrusts of a handsaw.

"The truth," Caroline said, "is that forty-eight hours sounds just about right to me. I don't want my children looking back on Christmas as the time when everybody screamed at each other. Which basically seems to be unavoidable now. Your mother walks in the door with three hundred sixty days' worth of Christmas mania, she's been obsessing since the previous January, and then, of course, Where's that Austrian reindeer figurine-don't you like it? Don't you use it? Where is it? Where is it? Where is the Austrian reindeer figurine? She's got her food obsessions, her money obsessions, her clothes obsessions, she's got the whole ten-piece set of baggage which my husband used to agree is kind of a problem, but now suddenly, out of the blue, he's taking her side. We're going to turn the house inside out looking for a piece of thirteen-dollar gift-store kitsch because it has sentimental value to your mother-"

"Caroline."

"And when it turns out that Caleb-"

"This is not an honest version."

"Please, Gary, let me finish, when it turns out that Caleb did the kind of thing that any normal boy might do to a piece of gift-store crap that he found in the basement-"

"I can't listen to this."

"No, no, the problem is not that your eagle-eyed mother is obsessed with some garbagey piece of Austrian kitsch, no, that's not the problem-"

"It was a hundred-dollar hand-carved-"

"I don't care if it's a thousand dollars! Since when do you punish him, your own son, for your mother's craziness? It's like you're suddenly trying to make us act like it's 1964 and we're all living in Peoria. `Clean your plate!' `Wear a necktie!' `No TV tonight!' And you wonder why we're fighting! You wonder why Aaron rolls his eyes when your mom walks in the room! It's like you're embarrassed to let her see us. It's like, for as long as she's here, you're trying to pretend we live some way that she approves of. But I'm telling you, Gary, we have nothing to be ashamed of. Your mother's the one who should be embarrassed. She follows me around the kitchen scrutinizing me, like, as if I roast a turkey every week, and if I turn my back for one second she's going to pour a quart of oil into whatever I'm making, and as soon as I leave the room she's going to root through the trash like some fucking Food Police, she's going to take food from the trash and feed it to my children-"

"The potato was in the sink, not the trash, Caroline."

"And you defend her! She goes outside to the trash barrels to see what other dirt she can dig up, and disapprove of, and she's asking me, literally every ten minutes, How's your back? How's your back? How's your back? Is your back any better? How'd you hurt it? Is your back any better? How's your back? She goes looking for things to disapprove of, and then she tries to tell my children how to dress for dinner in my house, and you don't back me up! You don't back me up, Gary. You start apologizing, and I don't get it, but I'm not doing it again. Basically, I think your brother's got the right idea. Here's a sweet, smart, funny man who's honest enough to say what he can and can't tolerate in the way of get-togethers. And your mother acts like he's this huge embarrassment and failure! Well, you wanted the truth. The truth is I cannot stand another Christmas like that. If we absolutely have to see your parents, we're doing it on our own turf. Just like you promised we always would."

A pillow of blue blackness lay on Gary's brain. He'd reached the point on the post-martini evening downslope where a sense of complication weighed on his cheeks, his forehead, his eyelids, his mouth. He understood how much his mother infuriated Caroline, and at the same time he found fault with almost everything that Caroline had said. The rather beautiful wooden reindeer, for example, had been stored in a well-marked box; Caleb had broken two of its legs and hammered a roofing nail through its skull; Enid had taken an uneaten baked potato from the sink and sliced it and fried it for Jonah; and Caroline hadn't bothered to wait until her in-laws had left town before depositing in a trash barrel the pink polyester bathrobe that Enid had given her for Christmas.

"When I said I wanted the truth," he said, not opening his eyes, "I meant I saw you limping before you ran inside."

"Oh, my God," Caroline said.

"My mother didn't hurt your back. You hurt your back."

"Please, Gary. Do me a favor and call Dr. Pierce."

"Admit that you're lying, and I'll talk about anything you want. But nothing's going to change until you admit that."

"I don't even recognize your voice."

"Five days in St. Jude. You can't do that for a woman who, like you say, has nothing else in her life?"

"Please come back to me."

A jolt of rage forced Gary's eyes open. He kicked the sheet aside and jumped out of bed. "This is a marriage-ender! I can't believe it!"

"Gary, please-"

"We're going to split up over a trip to St. Jude!"

And then a visionary in a warm-up jacket was lecturing to pretty college students. Behind the visionary, in a pixilated middle distance, were sterilizers and chromatography cartridges and tissue stains in weak solution, long-necked medicoscientific faucets, pinups of spread-eagled chromosomes, and diagrams of tuna-red brains sliced up like sashimi. The visionary was Earl "Curly" Eberle, a small-mouthed fifty-year-old in dime-store glasses, whom the creators of the Axon Corporation's promotional video had done their best to make glamorous. The camera work was nervous, the lab floor pitched and lurched. Blurry zooms zeroed in on female student faces aglow with fascination. Curiously obsessive attention was paid to the back of the visionary head (it was indeed curly).

"Of course, chemistry, too, even brain chemistry," Eberle was saying, "is basically just manipulation of electrons in their shells. But compare this, if you will, to an electronics that consists of little two- and three-pole switches. The diode, the transistor. The brain, by contrast, has several dozen kinds of switches. The neuron either fires or it doesn't; but this decision is regulated by receptor sites that often have shades of offness and on-ness between plain Off and plain On. Even if you could build an artificial neuron out of molecular transistors, the conventional wisdom is that you can still never translate all that chemistry into the language of yes/no without running out of space. If we conservatively estimate twenty neuroactive ligands, of which as many as eight can operate simultaneously, and each of these eight switches has five different settings-not to bore you with the combinatorics, but unless you're living in a world of Mr. Potato Heads, you're going to be a pretty funny-looking android."

Close-up of a turnip-headed male student laughing.

"Now, these are facts so basic," Eberle said, "that we ordinarily wouldn't even bother spelling them out. It's just the way things are. The only workable connection we have with the electrophysiology of cognition and volition is chemical. That's the received wisdom, part of the gospel of our science. Nobody in their right mind would try to connect the world of neurons with the world of printed circuits."

Eberle paused dramatically.

"Nobody, that is, but the Axon Corporation."

Ripples of buzz crossed the sea of institutional investors who'd come to Ballroom B of the Four Seasons Hotel, in central Philadelphia, for the road show promoting Axon's initial public offering. A giant video screen had been set up on the dais. On each of the twenty round tables in the semidark ballroom were platters of satay and sushi appetizers with the appropriate dipping sauces.

Gary was sitting with his sister, Denise, at a table near the door. He had hopes of transacting business at this road show and he would rather have come alone, but Denise had insisted on having lunch, today being Monday and Monday being her one day off, and had invited herself along. Gary had figured that she would find political or moral or aesthetic reasons to deplore the proceedings, and, sure enough, she was watching the video with her eyes narrowed in suspicion and her arms crossed tightly. She was wearing a yellow shift with a red floral print, black sandals, and a pair of Trotskyish round plastic glasses; but what really set her apart from the other women in Ballroom B was the bareness of her legs. Nobody who dealt in money did not wear stockings.

WHAT IS THE CORECKTALL PROCESS?

"Corecktall," said the cutout image of Curly Eberle, whose young audience had been digitally pureed into a uniform backdrop of tuna-red brain matter, "is a revolutionary neurobiological therapy!"

Eberle was seated on an ergonomic desk chair in which, it now developed, he could float and swerve vertiginously through a graphical space representing the inner-sea world of the intracranium. Kelpy ganglia and squidlike neurons and eellike capillaries began to flash by.

`

"Originally conceived as a therapy for sufferers of PD and AD and other degenerative neurological diseases," Eberle said, "Corecktall has proved so powerful and versatile that its promise extends not only to therapy but to an outright cure, and to a cure not only of these terrible degenerative afflictions but also of a host of ailments typically considered psychiatric or even psychological. Simply put, Corecktall offers for the first time the possibility of renewing and improving the hard wiring of an adult human brain."

"Ew," Denise said, wrinkling her nose.

Gary by now was quite familiar with the Corecktall Process. He'd scrutinized Axon's red-herring prospectus and read every analysis of the company he could find on the Internet and through the private services that CenTrust subscribed to. Bearish analysts, mindful of recent gut-wrenching corrections in the biotech sector, were cautioning against investing in an untested medical technology that was at least six years from market. Certainly a bank like CenTrust, with its fiduciary duty to be conservative, wasn't going to touch this IPO. But Axon's fundamentals were a lot healthier than those of most biotech startups, and to Gary the fact that the company had bothered to buy his father's patent at such an early stage in Corecktall's development was a sign of great corporate confidence. He saw an opportunity here to make some money and avenge Axon's screwing of his father and, more generally, be bold where Alfred had been timid.

It happened that in June, as the first dominoes of the overseas currency crises were toppling, Gary had pulled most of his playing-around money out of Euro and Far Eastern growth funds. This money was available now for investment in Axon; and since the IPO was still three months away, and since the big sales push for it had not begun, and since the red herring contained such dubieties as give non-insiders pause, Gary should have had no trouble getting a commitment for five thousand shares. But trouble was pretty much all he'd had.

His own (discount) broker, who had barely heard of Axon, belatedly did his homework and called Gary back with the news that his firm's allocation was a token 2,500 shares. Normally a brokerage wouldn't commit more than five percent of its allocation to a single customer this early in the game, but since Gary had been the first to call, his man was willing to set aside 500 shares. Gary pushed for more, but the sad fact was that he was not a big-time customer. He typically invested in multiples of a hundred, and to save on commissions he executed smaller trades himself online.

Now, Caroline was a big investor. With Gary's guidance she often bought in multiples of a thousand. Her broker worked for the largest house in Philadelphia, and there was no doubt that 4,500 shares of Axon's new issue could be found for a truly valued customer; this was how the game was played. Unfortunately, since the Sunday afternoon when she'd hurt her back, Gary and Caroline had been as close to not speaking as a couple could be and still function as parents. Gary was keen to get his full five thousand shares of Axon, but he refused to sacrifice his principles and crawl back to his wife and beg her to invest for him.

So instead he'd phoned his large-cap contact at Hevy & Hodapp, a man named Pudge Portleigh, and asked to be put down for five thousand shares of the offering on his own account. Over the years, in his duciary role at CenTrust, Gary had bought a lot of stock from Portleigh, including some certifiable turkeys. Gary hinted now to Portleigh that CenTrust might give him an even larger portion of its business in the future. But Portleigh, with weird hedginess, had agreed only to pass along Gary's request to Daffy Anderson, who was Hevy & Hodapp's deal manager for the IPO.

There had then ensued two maddening weeks during which Pudge Portleigh failed to call Gary back and confirm an allocation. Online buzz about Axon was building from a whisper to a roar. Two related major papers by Earl Eberle's team-"Reverse-Tomographic Stimulation of Synaptogenesis in Selected Neural Pathways" and "Transitory Positive Reinforcement in Dopamine-Deprived Limbic Circuits: Recent Clinical Progress"-appeared in Nature and the New England Journal of Medicine within days of each other. The two papers received heavy coverage in the financial press, including a front-page notice in the Wall Street Journal. Analyst after analyst began to flash strong Buys for Axon, and still Portleigh did not return Gary's messages, and Gary could feel the advantages of his insiderly head start disappearing hour by hour .